Stereochemical Aspects of Drug Action and Disposition

Stereochemistry is an essential dimension in pharmacology and should be understood as such by all drug researchers whatever their background. When used as probes or as medicines, stereoisomeric drugs offer helpful pharmacological insights or innovative therapeutic strategies. This volume aims to guide and inspire drug researcher.

Preface.- Section 1. Chemical Aspects: 1. Recent Developments in Asymmetric Organic Synthesis:Principles and Examples. 2. Stereoselective separations: Recent Advances in Capillary Electrophoresis and High-Performance Liquid Chromatography. 3. Stereochemical Issues in Bioactive Natural Products. 4. Drug Racemization and Its Significance in Pharmaceutical Research. 5. Physical Properties and Crystal Structures of Chiral Drugs.- Section 2. Experimental Pharmacology.- 6. Chiral Recognition in Biochemical Pharmacology: An Overview. 7. Enantioselectivity in Drug-Receptor Interactions. 8. Mechanisms of Stereoselective Binding to Functional Proteins. 9. Stereoselective Drug-Channel Interactions. 10. Toxocilogical Aspects.- Section 3. Drug Absorption, Distribution, Metabolism, Elimination: 11. Enantioselective GI Absorption:The Role of Transporters. 12. Enentioselective Plasma and Tissue Binding. 13. Stereoselective Drug Metabolism and Drug Interactions. 14. Metabolic Chiral Inversion of 2-Arylpropionic Acids. 15. Stereoselective Renal Elimination.- Section 4. Implications for Drug Development and Therapy: 16. Regulatory Requirements for the Development of Chirally Active Drugs. 17. Improving Clinical Risk / Benefit Through Stereochemistry.-