Structure-Activity Relationships for Development of Neurokinin-3 Receptor Antagonists : Reducing Environmental Impact
2020 ed.
Book Details
Format
Hardback or Cased Book
Book Series
Springer Theses
ISBN-10
9811529647
ISBN-13
9789811529641
Edition
2020 ed.
Publisher
Springer Verlag, Singapore
Imprint
Springer Verlag, Singapore
Country of Manufacture
GB
Country of Publication
GB
Publication Date
Jan 24th, 2020
Print length
86 Pages
Weight
282 grams
Dimensions
24.40 x 16.40 x 1.20 cms
Product Classification:
PharmacologyPharmacologyPharmacy / dispensingOrganic chemistryBiochemistry
Ksh 16,200.00
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This book explores the possible development of neurokinin-3 receptor (NK3R) antagonists with reduced environmental impact. Pharmaceuticals are used to cure diseases and to alleviate symptoms in humans and animals.
This book explores the possible development of neurokinin-3 receptor (NK3R) antagonists with reduced environmental impact.
Pharmaceuticals are used to cure diseases and to alleviate symptoms in humans and animals. However, the stable, bioactive substances excreted by patients have unfavorable effects on non-target species. To overcome these disadvantages of these highly stable, potent substances, drug design to turn off bioactivity after release into the environment is needed.
The book describes the development of eco-friendly NK3R antagonists by introducing a labile functional moiety and substituting a scaffold. This resulted in a novel NK3R antagonist that oxidized into its inactive form when exposed to air. Further, the book presents an efficient and easily achievable synthetic method of creating triazolopiperazine scaffolds, as well as a structure-activity relationship study involving scaffold hopping for decomposable motifs, which led to a novel photodegradable NK3R antagonist.
Demonstrating that it is possible to develop compounds that convert into their inactive forms under environmental conditions, this book is useful for anyone interested in therapeutic agents with reduced environmental impact.
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