In recent years, Drosophila, with its powerful genetic tools and in-depth knowledge of its biology, has contributed greatly in understanding the basics of cancer biology. This book is intended to collect writings from leading scientists who use the Drosophila model to address fundamental questions related to different areas of cancer research. The topics will range from identification of cancer related genes and pathways, to how tumor cells interact with its microenvironment; and from the intrinsic defense mechanisms metazoans have evolved, to why cancer is deadly. What we have learned from this small creature will continue to help in our fight against cancer.
This volume provides a series of review articles that capture the advances in using the fruit fly, Drosophila melanogaster, model system to address a wide range of cancer-related topics. Articles in this book provide case studies that shed light on the intricate cellular and molecular mechanisms underlying tumor formation and progression. Readers will discover the beauty of the fly model’s genetic simplicity and the vast arsenal of powerful genetic tools enabling its efficient and adaptable use. This model organism has provided a unique opportunity to address questions regarding cancer initiation and development that would be extremely challenging in other model systems. This book provides a useful resource for a researcher who wishes to learn about and apply the Drosophila model to tackle fundamental questions in cancer biology, and to find new ways to fight against this devastating disease.
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