Vaccine Adjuvants

A cutting-edge review of the major research areas of adjuvant discovery, design, development, and use. The authors lay down a rational basis for vaccine adjuvant function and analyze a number of significantly distinct adjuvant-active molecules to illuminate the principles of their function and use.

Microbial Pathogenesis and the Discovery of Toll-Like Receptor Function Bruce Beutler Dendritic Cells: Targets for Immune Modulation by Microbes and Immunologists Bali Pulendran, Anshu Agrawal, Stephanie Dillon, and Sudhanshu Agrawal Achieving Transcriptional Specificity in NF-kB-Dependent Inflammatory Gene Expression Gioacchino Natoli Adjuvants and the Initiation of T-Cell Responses Matthew F. Mescher, Julie M. Curtsinger, and Marc Jenkins Mechanism for Recognition of CpG DNA Kiyoshi Takeda, Hiroaki Hemmi, and Shizuo Akira CpG ODN As a Th1 Immune Enhancer for Prophylactic and Therapeutic Vaccines Arthur M. Krieg and Heather L. Davis Modified Bacterial Toxins Ed C. Lavelle, Olive Leavy, and Kingston H. G. Mills Glycosylphosphatidylinositol Anchors As Natural Immunological Adjuvants Derived From Protozoan Parasites Ricardo T. Gazzinelli, Catherine Ropert, Igor C. Almeida, João S. Silva, and Marco A. Campos The Immunomodulatory Glycan LNFPIII/Lewis X Functions As a Potent Adjuvant for Protein Antigens Mitsuhiro Okano, Kazunori Nishizaki, Akram Da''dara, Paul Thomas, Michele Carter, and Donald A. Harn, Jr. Immune and Antiviral Effects of the Synthetic Immunomodulator Murabutide: Molecular Basis and Clinical Potential George M. Bahr Effect of QS-21 on Innate and Adaptive Immune Responses Charlotte Read Kensil, Gui Liu, Christine Anderson, and James Storey Monophosphoryl Lipid A and Synthetic Lipid A Mimetics As TLR4-Based Adjuvants and Immunomodulators Jory Baldridge, Kent Myers, David Johnson, David Persing, Christopher Cluff, and Robert Hershberg Microparticles and DNA Vaccines Kimberly Denis-Mize, Manmohan Singh, Derek T. O''Hagan, Jeffrey B. Ulmer, and John J. Donnelly Index