VEGF and Cancer

A comprehensive review of knowledge on the role of vascular endothelial growth factor (VEGF) in cancer. This work includes features such as: discussion of VEGF as potent angiogenic factor and its role in tumor angiogenesis; review of the biology, molecular properties and regulation of VEGF; and more.

1. VEGF and Its Receptors.- Activities of VEGF.- VEGF Isoforms.- Regulation of VEGF Gene Expression.- The VEGF Receptors.- Role of VEGF in Physiological Angiogenesis.- Role of VEGF in Pathologic Conditions.- Therapeutic Implications and Perspectives.- 2. Hypoxic Regulation of VEGF.- Transcriptional Regulation of VEGF.- Post Transcriptional Regulation of VEGF.- Abnormalities in the Hypoxic Regulation of VEGF.- 3. Molecular Mechanisms of VEGF-Induced Angiogenesis.- Angiogenesis.- The Role of Vascular Endothelial Growth Factor in Angiogenesis.- The VEGF Signal Cascade in Angiogenesis.- 4. Crosstalk between VEGF and Bd-2 in Tumor Progression and Angiogenesis.- Angiogenic Potential of Tumor Cells Overexpressing Bcl-2.- Role of Bcl-2 in VEGF-Promoted Survival of Tumor Cells.- Role of Bcl-2 in Endothelial Cells.- Clinical Relevance of VEGF and Bcl-2 Expression.- 5. Vascular Endothelial Growth Factor in Breast Cancer.- VEGF and Tumor Growth.- Serum VEGF and Breast Cancer.- VEGF and Clinical Consequences.- Future Strategies in Breast Cancer.- 6. VEGF and Tumor Progression in Human Melanoma.- VEGF in Tumor Angiogenesis.- Angiogenesis and Human Melanoma.- VEGF in Human Melanoma.- 7. VEGF in Esophageal Cancer.- VEGF in Squamous Cell Carcinoma of the Esophagus.- VEGF in Barrett''s Disease and Adenocarcinoma of the Esophagus.- Circulating VEGF Levels in Esophageal Carcinoma.- VEGF and MVD during Neoadjuvant Treatment of Esophageal Carcinoma.- VEGF-C and Lymphangiogenesis in Esophageal Carcinoma.- Anti-VEGF Treatment of Esophageal Carcinoma.- 8. VEGF in Colorectal Cancer.- Colon Cancer.- VEGF in Colorectal Cancer Progression.- Prognostic Value of VEGF in Colorectal Cancer Patients.- The Role of VEGF in Metastasis of Colorectal Cancer.- Anti-Angiogenic Therapy by Interference with the VEGF Pathway in Colorectal Cancer.- 9. Vascular Endothelial Growth Factor in Malignant Disease of the Central Nervous System.- VEGF in the Normal Brain.- VEGF Is Upregulated in Malignant Disease of the CNS.- Angiogenesis in Glioma.- Factors Influencing VEGF Production.- C6 Glioma Is an Excellent Model for the Study of High Grade Human Glioma with Regard to VEGF.- VEGF Is Responsible for the Virulent Nature of High Grade Gliomas.- Interrupting VEGF-Receptor Signaling Inhib its Glioma Growth in Preclinical Models.- Current Therapy of Glioma: VEGF Contributes to Treatment Failure.- 10. VEGF in Hematopoietic Malignancy.- The VEGFNEGF Receptor Pathway.- Hematopoietic and Endothelial Cells Share a Common Hematopoietic/Endothelial Progenitor Cell.- VEGF Bone Marrow Interact ions in Hematological Malignancy.- VEGF and Angiogenesis in Acute Leukemia and Myelodysplasia.- VEGF and Angiogenesis in Myeloproliferative Disorders.- VEGF and Angiogenesis in B-Cell Chronic Lymphocytic Leukemia.- VEGF and Angiogenesis in Lymphomas.- VEGF and Angiogenesis in Myeloma.- VEGF Signalling Pathways Asa Therapeutic Target in Hematological Malignancies.- 11. Targeting VEGF in Pancreatic Cancer.- Cancer Metastasis.- Tumor Angiogenesis.- Regulation of Angiogenesis by the Microenvironment.- VEGF/NPF:A Pro-Angiogenic Molecule.- Regulation ofVEGF/NPF Expression in Tumors.- Development of a Human Pancreatic Adenocarcinoma Model.- Anti-VEGF Therapy in Pancreatic Cancer.- Anti-Angiogenic Therapy: Clinical Implications.- 12. Effects of Fibrinogen and Associated Peptide Fragments on the Activation ofHuman Endothelial Cells by VEGF in Vitro.- Fibrinogen and Fibrin Formation.- Fibrinolysis.- Effects of Fibrinogen on Endothelial Cell Activation.- Fibrin, VEGF and Angiogenic Mechanisms.- Stimulation of VEGF Induced Angiogenesis by Fibrin E-Fragment.- Fibrinogen E-Fragment Inhibits VEGF Activation of Endothelial Cells.- The Effects of Other Fibrinogen/Fibrin Related Fragment on VEGF-Activation of Endothelial Cells.- 13. Vascular Endothelial Growth Factor (VEGF) and Its Role in Non-Endothelial Cells: Autocrine Signalling by VEGF.- VEGF in the Cardiovascular System.- VEGF and the Central Nervous System (...