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Recombinant Protein Production with Prokaryotic and Eukaryotic Cells. A Comparative View on Host Physiology : Selected articles from the Meeting of the EFB Section on Microbial Physiology, Semmering, Austria, 5th–8th October 2000 - 1st ed. Softcover of orig. ed. 2001

By: (Edited by) C. Lang , (Edited by) D. Mattanovich , (Edited by) D. Porro , (Edited by) G. Larsson , (Edited by) J. Teixeira de Mattos , (Edited by) J.A. Cole , (Edited by) Otto-Wilhelm Merten , (Edited by) P. Neubauer , (Edited by) P. Postma

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Ksh 31,600.00

Format: Paperback / Softback

ISBN-10: 9048157560

ISBN-13: 9789048157563

Edition: 1st ed. Softcover of orig. ed. 2001

Publisher: Springer

Imprint: Springer

Country of Manufacture: NL

Country of Publication: GB

Publication Date: Dec 1st, 2010

Print length: 400 Pages

Product Classification: Biochemistry
Proteins
Microbiology (non-medical)
Zoology & animal sciences
Biotechnology

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On the first sight one would expect the technology - including the physiology of the host strains - to be optimised in detail after a 20 year's period of development.
More then 20 years have passed now since the first recombinant protein producing microorganisms have been developed. In the meanwhile, numerous proteins have been produced in bacteria, yeasts and filamentous fungi, as weIl as higher eukaryotic cells, and even entire plants and animals. Many recombinant proteins are on the market today, and some of them reached substantial market volumes. On the first sight one would expect the technology - including the physiology of the host strains - to be optimised in detail after a 20 year''s period of development. However, several constraints have limited the incentive for optimisation, especially in the pharmaceutical industry like the urge to proceed quickly or the requirement to define the production parameters for registration early in the development phase. The additional expenses for registration of a new production strain often prohibits a change to an optimised strain. A continuous optimisation of the entire production process is not feasible for the same reasons.

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