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Target Validation in Drug Discovery

By: U.S.A.) Metcalf CA Moraga Incyte Corporation Brian W. (Chief Drug Discovery Officer (Author) , U.S.A.) Dillon PA Malvern Johnson & Johnson Discovery Research Centocor Susan (Senior Vice President (Author)

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Format: Hardback or Cased Book

ISBN-13: 9780123693938

Publisher: Elsevier Science Publishing Co Inc

Publication Date: Nov 1st, 2006

Dimension: 26.00 x 18.40 x 82.00 cms

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Presents a comprehensive framework for approaching target validation in drug discovery. This work begins with a description of enabling technologies, including aptamers, RNA interference, and proteomics. It, then, looks at biologic drug development with discussion of lessons learned from such well-known cases as Erbitux, Herceptin, and Avastin.

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